impact of the il-10 promoter gene polymorphisms in the severity of chronic hepatitis b infection
نویسندگان
چکیده
conclusions some il-10 promoter gene polymorphisms predisposed the infected hepatitis b virus cases to cirrhosis in our study population. patients and methods totally, 166 patients with chronic hepatitis b infection were enrolled. genotypes at different positions (i.e. -819, - 592, and - 1082) in the il-10 gene promoter were determined. results the c/a genotype at position -592, c/t genotype at position -819, and gcc/ata haplotype of the il-10 gene promoter were significantly more common in the patients with cirrhosis. the genotypes were significantly different between the hepatitis b e antigen (hbeag)-negative and hbeag-positive patients at position -592 (c/a and c/c), position -819 (c/c and c/t), and position -1082 (a/a and g/a). objectives the aim of this study was to evaluate the polymorphisms at different positions in the il-10 promoter gene in patients with chronic hepatitis b. background interleukin-10 (il-10) is an important anti-inflammatory cytokine. the polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis b infection.
منابع مشابه
Impact of the IL-10 Promoter Gene Polymorphisms in the Severity of Chronic Hepatitis B Infection
BACKGROUND Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection. OBJECTIVES The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in patients with chronic hepatitis B. PATIENTS AND METHODS Totally, 166 patien...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۵، شماره ۷، صفحات ۰-۰
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